NCT04129086

Ketamine for Acute Pain Management After Trauma

Ketamine for Acute Pain After Trauma: KAPT Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 305 (actual)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.

Conditions

• Trauma Injury
• Pain
• Opioid Use

Interventions

Type	Name	Description
DRUG	Ketamine plus usual care	Bolus of .35 mg/kg Infusion start @ 0.15 mg/kg/hr; titrate range is 0.1 - 0.25 mg/kg/hr for 24 to 48 hours after admission and each subsequent major surgery plus multi-modal pain therapy considered as standard of care. Standard of care medications include Acetaminophen 1000 mg po q6 hours, Naproxen 500 mg po q12 hours, Gabapentin 300 mg po q8 hours and Lidocaine patch q 12 hours.
DRUG	Usual Care	Standard of care medications include Acetaminophen 1000 mg po q6 hours, Naproxen 500 mg po q12 hours, Gabapentin 300 mg po q8 hours and Lidocaine patch q 12 hours.

Timeline

• Start date: 2020-07-01
• Primary completion: 2022-03-30
• Completion: 2022-09-30
• First posted: 2019-10-16
• Last updated: 2023-04-21
• Results posted: 2023-04-21

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study