NCT04128215

Sex Differences in Vascular Responses to Exercise

Sex Differences in Chronic and Acute Vascular Responses to Aerobic Exercise in Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 60 Years – 79 Years
• Healthy volunteers: Accepted

Summary

A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation. Regular aerobic exercise ameliorates endothelial dysfunction in healthy older men, but the data in healthy postmenopausal women are inconsistent with many studies showing no effect. The primary objective of this study was to examine sex differences in acute and chronic endothelial responses to exercise training in older men vs. older postmenopausal women.

Conditions

• Aging

Interventions

Type	Name	Description
BEHAVIORAL	Control Period	Participants completed an 8-week control period of normal lifestyle.
BEHAVIORAL	Exercise Period	Participants completed an 8-week exercise intervention period of remotely supervised home-based non-weight-bearing all-extremity high intensity interval training (NWA-HIIT). NWA-HIIT consisted of 4x4-min bouts at 90% of maximal heart rate (HRmax) interspersed by 3x3-min bouts at 70% of HRmax. A 10-min warm-up and 5-minute cool-down at 70% of HRmax were included.

Timeline

• Start date: 2019-11-22
• Primary completion: 2023-05-31
• Completion: 2023-05-31
• First posted: 2019-10-16
• Last updated: 2024-11-14
• Results posted: 2024-11-14

Locations

1 site across 1 country: United States