NCT04127968

Efficacy and Safety of Vitamin A Treatment for Children With Sepsis

Efficacy and Safety of Vitamin A Treatment for Children With Sepsis: a Randomized Placebo-controlled Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 450 (estimated)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 0 Months – 192 Months
• Healthy volunteers: Not accepted

Summary

The prevalence of vitamin A deficiency was found high in children with sepsis. Whether those patients will benefit from the vitamin A supplementation is unknown.

Detailed description

It was reported that the prevalence of vitamin A deficiency was highly as 58% in critically ill children with sepsis. However, whether those patients will benefit from the vitamin A supplementation is unknown. We design an randomized, double-blind, placebo-controlled, multi-center trial to investigate the effect of vitamin A supplementation on the outcome of critically ill children with sepsis.

Conditions

• Vitamin A Deficiency
• Pediatric
• Sepsis

Interventions

Type	Name	Description
DRUG	Vitamin A	Children in intervention group will receive 50,000 IU vitamin A after being randomized.
DRUG	Oil	Children in control group will receive equal volume of oil.

Timeline

• Start date: 2022-11-01
• Primary completion: 2023-12-31
• Completion: 2024-05-31
• First posted: 2019-10-16
• Last updated: 2022-01-04