NCT04119765

Plasma Oxalate in Patient With Short Bowel

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 47 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hyperoxaluria due to fat malabsorption is seen in patients suffering from short bowel and can lead to stones and nephrocalcinosis. Not all patients are prone to these renal complications. only urinary oxaluria is measured in practice. Plasma oxalate shouldn't increase theoretically in these patients. However recent report showed an increase of plasma oxalate in patient with enteric hyperoxaluria. The aim of this study is to assess the plasma oxalate distribution in this specific population to have a new tool to predict renal complication of these patients.

Conditions

• Short Bowel Syndrome
• Hyperoxaluria
• Hyperoxalemia

Interventions

Type	Name	Description
BIOLOGICAL	Blood sampling	blood sampling will be used to perform oxalemia and FGF23 quantitative analysis
BIOLOGICAL	Urine sampling	urine sampling will be used to measure glycolate urinary rate (glycolaturia) and to perform urinary inflammation markers quantitative analysis
PROCEDURE	Pulse Wave Velocity (PWV) measurement	PWV will be measured thank to the Complior® device
PROCEDURE	central pressure measurement	central pressure will be measured thank to the Complior® device

Timeline

• Start date: 2020-02-27
• Primary completion: 2022-05-04
• Completion: 2022-05-04
• First posted: 2019-10-08
• Last updated: 2022-07-21

Locations

1 site across 1 country: France