NCT04107090

Role of Lung Ultrasound In Assessment Of Recruitment Maneuvers In Ventilated Preterms With Respiratory Distress Syndrome and Its Correlation With Tracheal IL-6 Level

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 1 Hour – 2 Days
• Healthy volunteers: Not accepted

Summary

This work is designed to: 1. Evaluate the efficacy of lung ultrasonography in detecting opening and closing lung pressures in ventilated preterm neonates with respiratory distress syndrome. 2. Determine the efficacy of lung ultrasonography in optimizing lung volume and its correlation with pulmonary inflammatory reaction as evidenced by IL-6 level in tracheal aspirate.

Detailed description

The studied population included 44 preterm infants. Anthropometric measurements, gestational age, sex, mode of delivery, maternal disease and Apgar score were found to be matched in the two studied groups indicating successful randomization as seen in these balanced demographic variables between the groups. The studied population included 44 preterm infants. Then they were allocated randomly to one of 2 groups in order by admission: Group A: included 22 patients on whom the recruitment maneuver was applied guided by lung ultrasonography. Group B: included 22 patients on whom the recruitment maneuver was not ultrasound guided. This is considered the control group. Anthropometric measurements, gestational age, sex, mode of delivery, maternal disease and Apgar score were found to be matched in the two studied groups indicating successful randomization as seen in these balanced demographic variables between the groups.

Conditions

• Respiratory Distress Syndrome, Newborn

Interventions

Type	Name	Description
OTHER	lung recruitment maneuver	Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome
OTHER	tracheal IL-6 level	tracheal IL-6 level was measured before and after recruitment maneuver
OTHER	US guided lung recruitment maneuver	Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome guided by lung ultrasound

Timeline

• Start date: 2018-01-20
• Primary completion: 2019-03-01
• Completion: 2019-05-20
• First posted: 2019-09-27
• Last updated: 2019-09-27

Locations

1 site across 1 country: Egypt