NCT04105075

COPD in Obese Patients

Features of Chronic Obstructive Pulmonary Disease Clinical Course in Obese Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 176 (actual)
• Sponsor: Voronezh N.N. Burdenko State Medical Academy · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The study included 176 patients with COPD. The first group included 88 normal weight patients with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years. The second group included 88 patients with COPD and obesity: 64 men and 24 women, mean age 62.94 ± 5.96 years. We assessed the frequency of COPD exacerbations in last 12 months, the severity of symptoms such as dyspnea, sputum production, fatigue. Spirometry, six-minute walk test and analysis of body tissue type composition were performed. BODE index was calculated. Levels of leptin, adiponectin, interleukins-4,6,8,10, interferon-γ, c-reactive protein (CRP), tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum.

Conditions

• Copd
• Obese
• Obesity, Abdominal

Timeline

• Start date: 2018-09-09
• Primary completion: 2019-09-10
• Completion: 2019-09-20
• First posted: 2019-09-26
• Last updated: 2019-10-03

Locations

1 site across 1 country: Russia