NCT04103775

Mechanisms of Cognitive Change

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Colorado State University · Academic / Other
• Sex: All
• Age: 15 Years – 100 Years
• Healthy volunteers: Accepted

Summary

This study will determine whether targeted cognitive training, a low-cost and low-risk commercial cognitive remediation therapy, directly impacts therapeutic targets as well as secondary outcomes in college undergraduates. The active intervention will be compared to an active control condition (computer games). Participants will also attend CSU TILT (The Institute for Teaching and Learning) Academic Workshops.

Detailed description

The primary goal of this project is to investigate whether commercial cognitive remediation therapy improves cognitive functioning in college undergraduates. The secondary goal is to investigate neurophysiological, cognitive, and psychosocial mechanisms of change. The investigators will compare cognitive remediation therapy to computer games. The active control condition will allow the investigators to determine whether targeted cognitive training, as an adjunct to academic skills training provided by CSU TILT, provides significant improvement over computer games alone (which is also thought to provide some value as "brain training"). Participants who agree to enroll in the study will be randomized to one of two intervention arms: cognitive remediation (CR) or active control (AC). In the CR arm, participants will complete 20 hours of targeted cognitive training, in 30-min session, 5 days per week, over 8 weeks. The AC Arm will follow the same schedule, except that participants will complete video games (e.g., pong). All participants will repeat assessments at randomly determined midpoint, as well as after the 8 weeks of training have been completed.

Conditions

• Psychosis

Interventions

Type	Name	Description
BEHAVIORAL	Cognitive Remediation	See Cognitive Remediation Arm description.
BEHAVIORAL	Active Control	See Active Control Arm description.

Timeline

• Start date: 2019-09-20
• Primary completion: 2021-01-22
• Completion: 2021-01-22
• First posted: 2019-09-25
• Last updated: 2022-09-22

Locations

1 site across 1 country: United States