NCT04089943

The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

The Role of microRNA-210 in Regulating Oxidative Stress in Patients With Peripheral Artery Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 230 (actual)
• Sponsor: University of West Florida · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Accepted

Summary

MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.

Detailed description

The investigators will randomize 180 PAD patients that undergoing a revascularization operation in two groups: (1) an endovascular procedure or (2) an open bypass procedure. They are also planning to recruit 50 non-PAD healthy control subjects. The goal is to answer the main hypothesis that miR-210 gene expression is a master regulator of oxidative stress and is associated with mitochondrial dysfunction, oxidative metabolism, walking function and quality of life.

Conditions

• Peripheral Arterial Disease
• Vascular Diseases, Peripheral
• Arterial Occlusive Diseases
• Atherosclerosis

Interventions

Type	Name	Description
PROCEDURE	Revascularization operation	Participants will be randomized into an endovascular or open bypass procedure.
OTHER	Control group	Healthy non-PAD participants will be recruited for the study.

Timeline

• Start date: 2019-09-15
• Primary completion: 2024-08-29
• Completion: 2025-08-25
• First posted: 2019-09-13
• Last updated: 2026-02-23

Locations

2 sites across 1 country: United States