NCT04076215

Biochemical and Physiological Response to Stressogenic Stimuli

Measuring the Biochemical and Physiological Response to Controlled Stressogenic Stimuli

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Nadav Goldental · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

Post-traumatic stress disorder (PTSD) is characterized by physiological changes, some of which are thought to be chronic, while others are observed in response to stressogenic stimuli. A psychiatric diagnosis of PTSD is currently based mainly on non-quantitative elements, such as interviews and subjective impressions. Discernable patterns of stress-related measures may constitute a physiological and biochemical phenotype characteristic of PTSD, which may serve as a biomarker and support diagnostic decisions, as well as personalized treatment plans. The current study is aimed at examining the possibility of basing a psychiatric diagnosis by measuring changes in the biochemical phenotype of participants with PTSD. Physiological and biochemical data will be collected from participants with and without PTSD using wearable sensors and adhesive biosensor patches. The data will be collected in two conditions: in a neutral, quiet situation, and during and following exposure to controlled stressogenic stimuli.

Conditions

• Post Traumatic Stress Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Stressogenic stimulus	Participants will be exposed to an anxiety-provoking stimulus for 15-20 minutes, in a controlled setting
DEVICE	Biobeat smart watch and adhesive biosensor patches.	Physiological and biochemical measures will be obtained using the Biobeat smart watch and adhesive biosensor patches.

Timeline

• Start date: 2019-09-01
• Primary completion: 2020-02-01
• Completion: 2020-06-01
• First posted: 2019-09-03
• Last updated: 2019-09-03