NCT04057274

Acute Effect of modeRate-intensity aerOBIc Exercise on Colon Cancer Cell Growth

Effect of a Single Bout of Moderate-intensity Aerobic Exercise on Colon Cancer Cell Growth in Vitro

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Northumbria University · Academic / Other
• Sex: Male
• Age: 50 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This study involves drawing blood samples from men before and after they perform 30-minutes of moderate-intensity aerobic exercise. The investigators will evaluate whether adding the exercise serum to colon cancer cells in a dish can reduce the growth of the cells compared to the resting serum. Note: serum is the liquid part of the blood that carries hormones and metabolites around the body.

Detailed description

Regular exercise is associated with a reduced risk of developing colon cancer. However, the mechanisms underpinning the anti-cancer effect of exercise are not yet fully understood. A recent theory suggests that each time you exercise, the short-lasting spikes in circulating hormones can suppress the growth of cancer cells. Hence, every exercise bout could have a direct anti-cancer effect. This study will recruit men with an increased of colon cancer and explore whether incubating colon cancer cells with serum collected after a bout of moderate-intensity aerobic exercise influences cell viability in vitro.

Conditions

• Colon Adenocarcinoma
• Colon Cancer

Interventions

Type	Name	Description
OTHER	Exercise assessment	The moderate-intensity aerobic interval exercise will be performed on a cycle ergometer under the supervision of trained staff in an exercise science laboratory. Participants will perform a 5 to 10-minute warm-up that begins by pedalling against a light resistance (60 W) and progressively increases in resistance until a target heart rate of 50-60% heart rate reserve is achieved. Participants will then complete 6 x 5-minute bouts at 60% heart rate reserve whilst maintaining a cadence of 60 rev·min-1, separated by 2.5-minutes of pedalling against light resistance (60 W). The session will finish with a cool-down at light resistance (60 W) lasting 10-minutes.

Timeline

• Start date: 2019-09-23
• Primary completion: 2020-03-06
• Completion: 2020-09-30
• First posted: 2019-08-15
• Last updated: 2020-08-20

Locations

2 sites across 1 country: United Kingdom