NCT04055181

Influence of rTMS on Symptoms and Cognitive Function in Patients With Psychiatric Disorders

Influence of rTMS on Symptoms and Cognition in Patients With Psychiatric Disorders

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 800 (actual)
• Sponsor: Beijing HuiLongGuan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation (rTMS) on the symptoms and cognitive functioning in patients with psychiatric disorders

Detailed description

OBJECTIVE: This study aimed to evaluate the efficacy of high-frequency rTMS over left dorsolateral prefrontal cortex in the treatment of symptoms and cognitive functioning in 200 chronic patients with schizophrenia and 200 patients with major depressive disorders METHODS: 1. Clinical Trial：The study consists of 4 weeks of treatment. 2. Assess Procedures: 2.1 Primary Outcome Variable-Psychopathology: The psychopathology of patients was assessed by three clinical trained staff, who were blind to treatment protocols, using the Positive and Negative Syndrome Scale (PANSS) or DSM-IV for depression, and repeatable battery for the assessment of neuropsychological status(RBANS).Patients are interviewed at screening, at at baseline, 4 weeks, 16 weeks. 2.2 Side effects: The side effect rating scale (UKU) was used to assess the side effect at baseline, 4 weeks, and 16 weeks. 2.3 Weight gain measurement: weight gain every week

Conditions

• Schizophrenia
• Major Depressive Disorder

Interventions

Type	Name	Description
DEVICE	rTMS in schizophrenia Controls	all procedures were identical to "rTMS in schizophrenia patients" group except they were the non-magnetized steel cylinders, instead of cylindrical magnets, that were rotated.
DEVICE	rTMS in schizophrenia patients	10 Hz stimulations over left DLPFC occurred at a power of 110% of MT for 27-s intervals with 20s intertrain interval. 20 minutes were administered each day (Monday-Friday) for 4 consecutive weeks
DEVICE	rTMS in major depressive disorders controls	all procedures were identical to "rTMS in major depressive disorders patients" group except they were the non-magnetized steel cylinders, instead of cylindrical magnets, that were rotated.
DEVICE	rTMS in major depressive disorders patients	10 Hz stimulations over left DLPFC occurred at a power of 110% of MT for 27-s intervals with 20s intertrain interval. 20 minutes were administered each day (Monday-Friday) for 4 consecutive weeks

Timeline

• Start date: 2018-12-01
• Primary completion: 2019-12-30
• Completion: 2020-01-30
• First posted: 2019-08-13
• Last updated: 2021-06-09

Locations

6 sites across 1 country: China