NCT04049591

Higher vs. Lower Dose Heparin for PCI

A Randomized Trial of Higher vs. Lower Dose Heparin for PCI

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 16,000 (estimated)
• Sponsor: Population Health Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

HD PCI is a multicenter, randomized, registry-based, cluster crossover design trial of higher dose versus lower dose heparin in patients undergoing elective percutaneous coronary intervention (PCI).

Detailed description

The primary objective of HD PCI is to compare the effect of a policy of higher dose heparin (100 U/kg) use to a policy of lower dose heparin (70 U/kg) use on death, myocardial infarction (MI) or target vessel revascularization (TVR) in patients undergoing elective percutaneous coronary intervention (PCI).

Conditions

• Cardiovascular Diseases
• Percutaneous Coronary Intervention

Interventions

Type	Name	Description
DRUG	Higher Dose UFH	Centre wide policy of administering 100 U/kg bolus of intravenous UFH for elective PCI procedures
DRUG	Lower Dose UFH	Centre wide policy of administering 70 U/kg bolus of intravenous UFH for elective PCI procedures

Timeline

• Start date: 2022-03-02
• Primary completion: 2024-10-08
• Completion: 2025-12-01
• First posted: 2019-08-08
• Last updated: 2025-07-31

Locations

1 site across 1 country: Canada