NCT04036552

The Associations Between Dietary Choline, Genetics and Anxiety/Depression

The Association Between Dietary Choline, Genetics and Anxiety/Depression

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: St Mary's University College · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The associations between dietary choline, genetics and anxiety/depression

Detailed description

Choline, previously considered to be a vitamin, is an essential nutrient involved in a plethora of biological pathways. Choline status is thought to be associated with depression and anxiety, however, the lack of evidence regarding the exact mechanism of its action warrants further investigation. This study aims to explore the associations between dietary choline and depression and anxiety in healthy individuals and how these may differ according to genetics, specifically Phosphatidylethanolamine N-Methyltransferase gene involved in endogenous and exogenous choline metabolism. Establishing these associations could reinforce the need for future intervention trials that could in turn establish causality and determine the mechanistic effects of dietary choline and the PEMT gene activity on depression/anxiety

Conditions

• Choline Deficiency
• Anxiety
• Depression

Timeline

• Start date: 2019-08-01
• Primary completion: 2019-10-03
• Completion: 2019-10-03
• First posted: 2019-07-29
• Last updated: 2019-07-29

Locations

1 site across 1 country: United Kingdom