NCT04034706

Transcriptional and Epigenetic Program of PCOS Women

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 108 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The main goal is to reveal differences in global gene expression in two different adipose tissue (AT) depots of females with and without polycystic ovary syndrome (PCOS) and how these are influenced by upstream epigenetic markers

Conditions

• PCOS

Interventions

Type	Name	Description
OTHER	DEXA	DEXA Scans will be performed to measure body fat and estimate muscle mass using a General Electric Lunar iDXA whole-body scanner.
OTHER	Magnetic Resonance (MR) Assessment of the Abdomen	Include measures to assess liver lipid content and stiffness and perform volumetric fat quantitation.
OTHER	MR assessment of Whole Body Fat	Volumetric measurement of fat, muscle and bone
PROCEDURE	Adipose tissue biopsy	0.5 cm incision of the upper-outer right vastus lateralis, and either a 3-4mm Mercedes Liposuction needle, or a 4-6 mm Bergstrom needle will be inserted to aspirate approximately 7 grams of adipose tissue.
OTHER	Oral glucose tolerance test	Glucose tolerance will be assessed with a 75 g oral glucose tolerance test (OGTT). Subjects will be studied after an overnight fast.

Timeline

• Start date: 2020-01-31
• Primary completion: 2023-04-12
• Completion: 2025-12-01
• First posted: 2019-07-26
• Last updated: 2025-03-13

Locations

1 site across 1 country: United States