NCT04017767

Motor Plasticity, Intermittent Hypoxia and Sleep Apnea

Intermittent Hypoxia (IH), Respiratory and Motor Plasticity, and Sleep Apnea in Spinal Cord Injury (SCI)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to learn about the effect of sleep apnea and low oxygen on muscle strength and lung function in people with chronic spinal cord injury.

Conditions

• Sleep Apnea, Obstructive
• Spinal Cord Injuries
• Hypoxia

Interventions

Type	Name	Description
PROCEDURE	Induced Acute Intermittent Hypoxia (AIH)	AIH will be administered on days 1-3. Each day entails 15 and 90 second hypoxic intervals (Fraction of Inspired Oxygen (FIO2) = 0.09) alternating with 60-second normoxic intervals (FIO2 = 0.21).
DEVICE	AIH mask	Induced Intermitted hypoxia will be delivered via the AIH mask. The mask has two one-way valves restricting inspiration to the top valve and expiration to the bottom valve. Hypoxic and normoxic gas mixtures will be delivered through the top valve.

Timeline

• Start date: 2021-07-16
• Primary completion: 2025-07-01
• Completion: 2025-07-01
• First posted: 2019-07-12
• Last updated: 2025-09-08

Locations

1 site across 1 country: United States