NCT04016194

Prediction of Survival in Children With Cystic Fibrosis Using the Multiple-breath Washout

Multiple-breath Washout for Lung Function Testing in Children With Cystic Fibrosis: Predictive for Survival?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 3 Years
• Healthy volunteers: Not accepted

Summary

Retrospective cohort study using routinely collected annual data on lung clearance index (LCI) in combination with clinical data to predict survival in patients with Cystic Fibrosis. The primary study endpoint is the association of LCI with the compound outcome survival or lung transplantation in patients with CF.

Detailed description

Retrospective analysis of longitudinal data collected during clinically routine from approximately 200 patients with CF aged 3 years or more between 01.01.1980 and 31.12.2005. The overall aim of this project is to retrospectively assess whether LCI measured for clinical purposes during school age is predictive for survival or lung transplantation in adulthood. For this, the investigators will assess in a systematic way clinically measured LCI and relate them with the compound outcome survival or lung transplantation retrospectively.

Conditions

• Cystic Fibrosis
• Death
• Lung Transplantation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Lung function testing	Multiple-breath washout (MBW) is a safe, easy and sensitive lung function test using inert gases such as Nitrogen (N2) to assess efficiency of ventilation distribution. The latter can be estimated by the lung clearance index (LCI), an established study end-point in patients with CF

Timeline

• Start date: 1990-01-01
• Primary completion: 2005-12-01
• Completion: 2005-12-01
• First posted: 2019-07-11
• Last updated: 2019-07-11

Locations

2 sites across 1 country: Switzerland