NCT04008693

Aging, Aged Garlic, Vascular Function and Muscle Oxygenation

Effect of Aged Garlic on Vascular Function and Muscle Oxygenation Responses in the Elderly

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Universidade Federal do Rio de Janeiro · Academic / Other
• Sex: All
• Age: 60 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The number of elderly individuals affected by cardiovascular diseases has been increasing in our country. Garlic (Allium sativum) has been associated with decrease of reactive species of oxygen, hypertension, high cholesterol, platelet aggregation, blood coagulation and especially cardiovascular diseases. The present study evaluated the effects of a garlic supplementation on vascular function and blood pressure in the elderly at cardiometabolic risk. Twenty-eight elderly individuals were submitted to an ingestion of four capsules of an aged garlic extract (KYOLIC® Aged Garlic Extract™). Muscle oxygenation and function were measured 180 min after interventions. Urinary thiosulfate, blood nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline and 180 min after interventions.

Conditions

• Aging
• Hypertension
• Dyslipidemias
• Abdominal Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Aged Garlic Extract	2.400 mg (four capsules) of a nutritional supplement of aged garlic extract (Kyolic® Hi-Po Formula - Kyolic)
OTHER	Placebo	800 mg of maltodextrin (four capsules)

Timeline

• Start date: 2019-08-26
• Primary completion: 2020-01-30
• Completion: 2020-03-30
• First posted: 2019-07-05
• Last updated: 2020-05-19

Locations

1 site across 1 country: Brazil