NCT03996382

Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Aarhus University Hospital Skejby · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction. Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand. This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.

Conditions

• Amyloidosis Cardiac
• Carpal Tunnel Syndrome

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	DPD Scintigraphy	Confirms/Refutes diagnosis of cardiac amyloidosis.

Timeline

• Start date: 2019-06-17
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2019-06-24
• Last updated: 2021-10-08

Locations

1 site across 1 country: Denmark