Trials / Completed
CompletedNCT03991286
The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycystic Ovary Syndrome
The Effect of Astaxanthin on Oxidative Stress Indices in Serum, and Induction of Signaling Pathways in Granulosa Cells in Patients With Polycystic Ovary Syndrome
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 48 (actual)
- Sponsor
- Tehran University of Medical Sciences · Academic / Other
- Sex
- Female
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Not accepted
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age It is hypothesized that ∼20 fold increase in reactive oxygen species (ROS) generation in Follicular fluid (FF) and granulosa cells of PCOS women plays an adverse role in affecting the IVF success rate. Astaxanthin (3,3'-dihydroxy-β,β'-carotene-4,4'-dione) is a nonprovitamin A carotenoid classified as a xanthophyll and is found in high amounts in the red pigment of crustacean shells (e.g., crabs, shrimp), salmon, trout, and asteroides. It has been demonstrated that astaxanthin displays a wide variety of biological activities, including anti-oxidative, anticancer, and anti-inflammatory effects. investigators aim to investigate the effect on Astaxanthin administrating on reducing of ROS in FF and induction of antioxidant response elements in PCOS women.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Astaxanthin 8 mg | experimental |
| OTHER | placebo | Matching placebo pill |
Timeline
- Start date
- 2020-01-20
- Primary completion
- 2020-11-01
- Completion
- 2021-04-07
- First posted
- 2019-06-19
- Last updated
- 2021-11-16
Locations
1 site across 1 country: Iran
Source: ClinicalTrials.gov record NCT03991286. Inclusion in this directory is not an endorsement.