NCT03985995

Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.

Detailed description

There are no studies investigating Cannabidiol (CBD) in an acute pain model in human beings. This is however of great clinical value because: 1. Patients are often treated insufficiently with the commonly used analgesics in acute pain therapy or the available selection of analgesics is limited by their contraindications and side-effects. 2. CBD could be an option to optimize pain therapy if the pain relief is not satisfactory. 3. CBD in contrast to ∆9-tetrahydrocannabinol (THC) has only few side effects and due to a possible dose reduction of other analgesics patients might benefit from a better side-effect profile. This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.

Conditions

• Pain Sensation
• Hyperalgesia
• Allodynia

Interventions

Type	Name	Description
DRUG	CBD 800 mg p.o	cannabidiol solution 100 mg/ml 8 ml in single-dose containers for per os administration. After a washout period of at least two weeks, the treatment group will be receiving a single-dose of the placebo solution 8 ml as a second intervention.
DRUG	Placebo p.o	single dose of oral placebo solution 8 ml matched to the IMP. After a washout period of at least two weeks, the control intervention group will be receiving the cannabidiol solution 100 mg/ml 8 ml as a second intervention.

Timeline

• Start date: 2019-09-16
• Primary completion: 2019-12-23
• Completion: 2019-12-23
• First posted: 2019-06-14
• Last updated: 2020-01-29

Locations

1 site across 1 country: Switzerland