NCT03969966

Citrate Anticoagulation for Postdilution Hemofiltration

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Heinrich-Heine University, Duesseldorf · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.

Detailed description

Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects. We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol. We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.

Conditions

• Acute Kidney Injury
• Critical Illness

Interventions

Type	Name	Description
OTHER	renal replacement therapy as clinically indicated	Continuous renal replacement therapy

Timeline

• Start date: 2019-01-14
• Primary completion: 2020-12-31
• Completion: 2021-07-31
• First posted: 2019-05-31
• Last updated: 2020-05-11

Locations

1 site across 1 country: Germany