NCT03966378

Reminerlization Potential of GSE Gel versusCPP-ACP in Carious White Spot Lesions in Post Orthodontic Patients

Reminerlization Potential of Grape Seeds Extract Gel Versus Casein Phosphopeptide-amorphous Calcium Phosphate in Carious White Spot Lesions in Post Orthodontic Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 13 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Assess the effectiveness of applying grape seed extract (GSE) gel versus casein phosphopeptide-amorphous calcium phosphate (MI) paste on remineralization of white spot lesion (WSLs) in post orthodontic patients.

Detailed description

The development of WSLs is a challenging problem in the track of orthodontic treatment. Especially in patients wearing fixed orthodontic appliances, plaque accumulation increases around brackets and bands and the pH on dental surfaces becomes acidic. These early lesions are willing to remineralization, arrest, reharden and revert to healthy enamel condition through a remineralization process involving the diffusion of minerals into the defective tooth structure. For this purpose various remineralizing agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and grape seed extract (GSE) have been used. This research is conducted for early intervention and treatment of the white spot lesions by non-invasive method.

Conditions

• Dental Caries

Interventions

Type	Name	Description
OTHER	Grape seeds extract	Grape seeds extract powder
OTHER	Casein-phosphopeptide/amorphous-calcium phosphate	CPP-ACP paste

Timeline

• Start date: 2019-10-03
• Primary completion: 2020-04-06
• Completion: 2020-05-10
• First posted: 2019-05-29
• Last updated: 2019-05-29