NCT03966261

The Role of Incretins in Bone Remodeling in Humans

INcrétines et REModelage OSseux

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 104 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The role of incretins (GIP and GLP-1) on cells and bone tissue has been shown in cellular and animal studies. In humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is unknown. The serum incretin concentration is low and increases rapidly after a meal. This increase is brief, incretins being rapidly degraded by dipeptidylpeptidase 4 (DPP-4). The dosage of these hormones is complex and the basal "normal" serum concentrations and after feeding in healthy subjects are unknown. Before any study on the effect of incretins on bone remodeling in humans, it is necessary to establish physiological concentrations of incretins in healthy subjects. The aim of this study is to estimate physiological concentrations of incretins in healthy subject.

Conditions

• Incretins
• Osteoporosis
• Bone Remodeling
• Healthy

Interventions

Type	Name	Description
OTHER	blood sample	we perform blood sample in healthy subject before and after a meal to measure incretins concentration

Timeline

• Start date: 2020-03-10
• Primary completion: 2022-05-02
• Completion: 2022-05-02
• First posted: 2019-05-29
• Last updated: 2024-01-11

Locations

1 site across 1 country: France