Trials / Recruiting

RecruitingNCT03959800

Molecular Basis of Pediatric Liver Cancer

Genetic and Molecular Basis of Pediatric Liver Cancer

Status: Recruiting
Phase: —
Study type: Observational
Enrollment: 1,600 (estimated)

Sponsor: University of Pittsburgh · Academic / Other
Sex: All
Age: 0 Years – 99 Years
Healthy volunteers: Not accepted

Summary

The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.

Detailed description

Pediatric liver cancers are rare, affecting at times no more than 1 in one million population. Understanding the molecular basis of these cancers is important in order to develop more accurate diagnoses and more effective treatments. Current classifications of these cancers are based on how these cancers look on diagnostic studies such as radiologic imaging or under the microscope. Such a classification system does not explain why a particular cancer has a different outcome from what is considered "usual" for that particular cancer. Nor does such a classification system explain why two different classes of cancers behave the same way. Understanding the genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition. To achieve these goals, large numbers of such cancer patients or affected tissue must be collected. This is not possible in any single institution, or any single country. The current project will collect biological samples such as residual tumor tissue, saliva, or blood from affected patients and their biological parents and families, along with clinical information about the cancer. These biological samples will be used to study the genes and how these genes work in tumor tissue and in non-tumor tissue. The results of this study will permit childhood liver cancers to be categorized on the basis of common defects in genes and their function.

Conditions

Timeline

Start date: 2015-06-22
Primary completion: 2028-06-30
Completion: 2029-06-30
First posted: 2019-05-22
Last updated: 2025-09-12

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT03959800. Inclusion in this directory is not an endorsement.