NCT03958474

Neurobehavioral Mechanisms of Choice in Opioid Use Disorder

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Joshua A. Lile, Ph.D. · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying abnormal task performance. A second objective is to identify an appropriate dose of intravenous remifentanil for subsequent studies in physically dependent individuals with opioid use disorder.

Conditions

• Opioid Use Disorder

Interventions

Type	Name	Description
DRUG	Oxycodone	Participants receive oxycodone or placebo.
DRUG	Remifentanil	Participants with a history of IV opioid use can opt to complete a session in which they receive remifentanil.

Timeline

• Start date: 2019-08-16
• Primary completion: 2025-07-10
• Completion: 2025-07-10
• First posted: 2019-05-22
• Last updated: 2025-10-24

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study