Trials / Terminated

TerminatedNCT03956745

Biomarkers for Circadian Timing in Healthy Adults

Proteomic and Transcriptomic Biomarkers of Circadian Timing

Status: Terminated
Phase: —
Study type: Observational
Enrollment: 15 (actual)

Sponsor: Brigham and Women's Hospital · Academic / Other
Sex: All
Age: 18 Years – 70 Years
Healthy volunteers: Accepted

Summary

Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.

Detailed description

There is an urgent need for a practical way to assess circadian timing accurately in both general and sleep medicine. The study is designed to assess the levels of different biomarkers in the blood taken from frequent samples across three separate sleep-wake conditions - Conventional/Normal sleep-wake conditions (baseline), extended wake/acute sleep deprivation (constant routine), and during irregular sleep-wake conditions (inverted day). Participants will be asked to complete medical, psychological, and sleep-wake evaluations prior to the study. Upon completion of screening, if eligible, participants will stay 7 consecutive days and nights in the sleep research laboratory within the hospital.

Conditions

Interventions

Type	Name	Description
BEHAVIORAL	sleep-wake timing	Study participants will have one inverted day when they are scheduled to sleep \~12h opposite their usual sleep time.
BEHAVIORAL	constant routine	Study participants will spend \~28-50 hours awake, inactive, sitting in bed, in constant lighting and temperature.

Timeline

Start date: 2021-06-01
Primary completion: 2023-12-31
Completion: 2025-04-30
First posted: 2019-05-21
Last updated: 2025-08-03

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT03956745. Inclusion in this directory is not an endorsement.