NCT03934411

Effect of Increased Pain Tolerance on Exercise Performance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

Clinical prescription and use of opioids is a clear problem in large parts of the world and has the recent years received an increasing publicity in sports. This is in particular due to the World Anti-Doping Agency monitoring list, which reveal that endurance athletes utilize the opioid Tramadol frequently with the aim to enhance performance according to anecdotal evidence. Studies investigating the effect of tramadol on exercise performance in healthy humans is limited to one study in moderate trained subjects. However, this effect may be different in highly trained subjects due to the effects of chronic exercise. Furthermore, ingestion of tramadol may impact motor-cognitive performance and it remains unknown whether tramadol can be detected in highly trained subjects following exercise. In the present study the investigators apply a randomized double-blind placebo-controlled counterbalanced cross-over design to investigate whether tramadol treatment improves a preloaded cycling time trial performance, whether it affects motor-cognitive performance and whether it is detectable following exercise.

Conditions

• Opioid Use
• Exercise

Interventions

Type	Name	Description
DRUG	Tramadol	The subjects will orally ingest 100 mg tramadol retard actavis
OTHER	Placebo	The subjects will orally ingest 100 mg calcium powder

Timeline

• Start date: 2018-03-01
• Primary completion: 2019-03-07
• Completion: 2019-03-07
• First posted: 2019-05-01
• Last updated: 2019-05-01

Locations

1 site across 1 country: Denmark