NCT03930563

Inorganic Nitrate and OSA

Acute Beetroot Juice Supplementation and Peripheral Chemoreflex Sensitivity in Patients With Obstructive Sleep Apnea

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Iowa · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study is to determine if acute beetroot juice supplementation reduces peripheral chemoreflex sensitivity in patients with obstructive sleep apnea. All subjects will consume low-dose (BRL), higher-dose (BRH), and placebo (BRP) beetroot juice randomly on three independent study visits. Beetroot juice also improves blood flow thus, the investigators will also measure blood flow to the carotid chemoreceptors.

Detailed description

Four-weeks of daily beetroot juice supplementation reduces peripheral chemoreflex sensitivity in healthy older adults who have 'normal' responses to acute hypoxia. Patients with obstructive sleep apnea have exaggerated peripheral chemoreflex sensitivity. It remains unknown if beetroot juice supplementation reduces peripheral chemoreflex sensitivity in patients with obstructive sleep apnea. Additionally, increasing blood flow to the peripheral chemoreceptors reduces sensitivity. Given that beetroot juice improves blood flow, the investigators will also measure common carotid artery blood flow at rest and during hypoxia.

Conditions

• Obstructive Sleep Apnea

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pre-beetroot juice supplementation	Before administering beetroot juice to subjects.
DIETARY_SUPPLEMENT	Post-beetroot juice supplementation	After administering beetroot juice to subjects.

Timeline

• Start date: 2019-06-12
• Primary completion: 2020-03-06
• Completion: 2020-03-06
• First posted: 2019-04-29
• Last updated: 2021-04-27

Locations

1 site across 1 country: United States