NCT03930446

Alcohol, Behavior, and Brain Imaging

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 21 Years – 29 Years
• Healthy volunteers: Accepted

Summary

To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.

Conditions

• Alcohol Drinking
• Binge Drinking
• Drinking Behavior
• Substance-Related Disorders
• Ethanol
• Physiological Effects of Drugs
• Central Nervous System Depressants

Interventions

Type	Name	Description
DRUG	Ethanol	The 0.8 g/kg body weight dose of oral alcohol (190-proof ethanol) will be divided into 4 servings of 0.2 g/kg each. The 0.8 g/kg dose is equivalent to 4 standard drinks, where a standard drink is defined as one 12 oz beer, one 5 oz glass of wine, or one 1.5 oz shot of 80 proof alcohol. Women will receive a reduced dose (0.68 g/kg) to account for sex differences in total body water
OTHER	Placebo	The placebo beverage will consist of the cranberry or orange juice plus 1% alcohol added as a taste mask. All beverages will be sprayed with an alcoholic mist to provide a strong alcoholic scent.

Timeline

• Start date: 2016-01-01
• Primary completion: 2019-05-30
• Completion: 2019-05-30
• First posted: 2019-04-29
• Last updated: 2022-04-25
• Results posted: 2022-04-25