NCT03921931

Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study

Assessment of Retinal Photoreceptor Outer Segment Length With Optical Coherence Tomography Before and After Light Stimulation - a Pilot Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.

Conditions

• Macular Degeneration, Dry
• Primary Open-angle Glaucoma

Interventions

Type	Name	Description
OTHER	White light stimulation	Stimulation of the retina with white light

Timeline

• Start date: 2018-11-26
• Primary completion: 2026-05-31
• Completion: 2026-05-31
• First posted: 2019-04-19
• Last updated: 2025-05-16

Locations

1 site across 1 country: Austria