NCT03916341

Smoking and Ventricular Repolarization

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.

Detailed description

Non-user or chronic electronic cigarette (EC) users will use an EC or control on three occasions:1) EC with nicotine, 2) EC without nicotine, 3) empty EC (control). Chronic tobacco cigarette (TC) smokers will use a TC or control on three occasions: 1) TC with nicotine (subject's own brand), 2) research TC with very low nicotine, 3) straw (control). The electrocardiogram will be recorded before and after acute exposures and analyzed for parameters representative of ventricular repolarization.

Conditions

• Sudden Cardiac Death
• Prolonged QTc Interval

Interventions

Type	Name	Description
OTHER	EC with nicotine	Use an EC with nicotine for up to 30 minutes
OTHER	EC without nicotine	Use an EC without nicotine for up to 30 minutes
OTHER	control	sham control
OTHER	TC with nicotine (own brand)	smoke a TC
OTHER	research TC with very low level nicotine	smoke a research TC with very low level nicotine

Timeline

• Start date: 2019-10-01
• Primary completion: 2023-04-10
• Completion: 2023-04-10
• First posted: 2019-04-16
• Last updated: 2023-10-04

Locations

1 site across 1 country: United States