Trials / Completed
CompletedNCT03914118
Modafinil to Prevent Postoperative Cognitive Decline
An Examination of the Effects of Modafinil (Provigil) or Placebo on Neurocognitive Testing After General Anesthesia for Non-Cardiac Surgery in an Older Population
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 137 (actual)
- Sponsor
- The Cooper Health System · Academic / Other
- Sex
- All
- Age
- 65 Years – 99 Years
- Healthy volunteers
- Accepted
Summary
Postoperative cognitive dysfunction is a well-recognized complication of surgery. The aim of the study is to investigate whether cognitive dysfunction is reduced by the use of modafinil as shown by neurocognitive testing.The treatment effects will be evaluated compared to placebo as well as a non-surgical group.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Preoperative modafinil + postoperative placebo | 200 mg modafinil pre-operatively and placebo immediately post-operatively. |
| DRUG | Preoperative modafinil + postoperative modafinil | 200 mg modafinil pre-operatively and 200 mg modafinil immediately post-operatively. |
| DRUG | Preoperative placebo + postoperative placebo | Placebo pre-operatively and placebo immediately post-operatively. |
Timeline
- Start date
- 2008-01-01
- Primary completion
- 2013-01-31
- Completion
- 2013-01-31
- First posted
- 2019-04-16
- Last updated
- 2023-09-29
Source: ClinicalTrials.gov record NCT03914118. Inclusion in this directory is not an endorsement.