NCT03909477

Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

Longitudinal Study of Xenon-129 MRI Imaging of Effects of Cannabis Smoking on Lung Structure and Function

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Western University, Canada · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

Detailed description

This is a longitudinal study of the long-term lung health impact of cannabis smoking in adults using xenon-129 (129Xe) MRI over three years. Males and females between the ages of 18 to 85 years with a history of cannabis smoking will be screened, and those who satisfy all inclusion and exclusion criteria will undergo study visits for up to 3 years, with visits every 12 ± 3 months, for a total of up to four study visits. Each study visit will include collection of patient smoking history and vital signs. At Visit 1 and 4, 129-Xe MRI, spirometry, plethysmography for airways resistance (Raw) and lung volumes, forced oscillation technique (FOT) and multiple breath nitrogen washout (MBNW) for the lung clearance index (LCI) will all be performed pre- and post-bronchodilator. Blood will be drawn for blood eosinophil count, and sputum induction will be done to measure sputum eosinophils. A CT will also be done at Robarts Research Institute, or at University Hospital, London Health Sciences Centre next door to Robarts. Visit 2 will be a telephone call to complete questionnaires. Visit 3 will include spirometry and questionnaires only. Participants 35 years of age or older will complete a six minute walk test (6MWT) for the distance walked (6MWD), pre and post oxygen saturation, perceived dyspnea (Modified Borg Scale) and perceived exertion (Borg's rating of perceived exertion). These participants will complete the St. George's Respiratory Questionnaire (SGRQ). Participants under the age of 35 will complete Cardio Pulmonary Exercise Testing to assess exercise capacity, and the American Thoracic Society Questionnaire (ATSQ).

Conditions

• Cannabis Use
• Cannabis Smoking
• Marijuana Smoking
• Marijuana Usage

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Hyperpolarized Xenon-129 MRI of the lungs	Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas
DIAGNOSTIC_TEST	Computed Tomography (CT)	Participants will undergo a CT scan of the thoracic cavity
DIAGNOSTIC_TEST	Pulmonary Function Tests (PFTs)	Participants will have their lung function evaluated using PFTs
DIAGNOSTIC_TEST	Six Minute Walk Test (6MWT)	Participants \>35 years of age will perform the six minute walk test as a measure of exercise capacity
DIAGNOSTIC_TEST	Cardiopulmonary exercise testing (CPET)	Participants \<35 will perform cardiopulmonary exercise testing as a measure of exercise capacity
DIAGNOSTIC_TEST	Sputum analysis	Participants will provide a sputum sample that will be analysed for eosinophils
DIAGNOSTIC_TEST	Blood analysis	Participants will have their blood drawn and analysed for eosinophil count.

Timeline

• Start date: 2022-06-01
• Primary completion: 2030-12-01
• Completion: 2030-12-01
• First posted: 2019-04-10
• Last updated: 2025-08-15

Locations

1 site across 1 country: Canada