NCT03900000

Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease

Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease: Does a Successful Treatment of Orthostatic Hypotension Measurably Enhance Attention and Memory Functions in Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: RWTH Aachen University · Academic / Other
• Sex: All
• Age: 40 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

Study on orthostatic Hypotension in Parkinson's disease

Detailed description

Orthostatic hypotension (OH) in Parkinson's disease (PD) may not only be related to dizziness or light headedness but to deficits in attention, visual, and verbal memory. Would a successful treatment of OH which includes physiotherapy significantly improve OH and these cognitive deficits? By means of a randomized cross-over trial, we want to measure and compare the effects of OH therapy on orthostatic tolerance, as well as on attention, visuo-spatial working memory, and verbal memory in patients with PD. If confirmed, therapy of orthostatic hypotension would provide a sound and simple approach to improve those cognitive deficits originating from orthostatic hypotension.

Conditions

• Hypotension, Orthostatic
• Parkinson Disease
• Autonomic Failure
• Cognitive Impairment

Interventions

Type	Name	Description
OTHER	Physiotherapy	Ambulatory leg-muscle oriented physiotherapy (2 x 45 minutes per week for at least 8 weeks) at Aachen University Hospital. Daily protocol of leg muscle training, exercises, sufficient fluid intake of 2liter/day, pressure stockings.

Timeline

• Start date: 2014-05-01
• Primary completion: 2018-10-31
• Completion: 2018-10-31
• First posted: 2019-04-02
• Last updated: 2023-07-05

Locations

1 site across 1 country: Germany