NCT03898531

Mineral Nano Pathology

Mineral-Nano-Pathology : Wear of Hip Implants

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 55 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hip arthroplasty is a treatment widely used in most inflammatory, traumatic and degenerative conditions of this joint. The longevity of implants may be disappointing in some cases, despite the promising results obtained during in vitro simulations. Early loco-regional or systemic dissemination, known since the 1990s, of wear particles from these prosthesis may reduce their life span. The analysis of the particles in the synovial fluid and in the articular tissues by electron microscopy after digestion or directly by optical microscopy, will improve the knowledge on the mechanisms of wear. This category 3 study is based on the case-control model and will be conducted in a national reference center (hospital la Croix-Rousse- Lyon). It will include a population of adult patients.

Conditions

• Arthroplasty

Interventions

Type	Name	Description
PROCEDURE	hip prosthesis removed metal / polyethylene, simple mobility	Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/polyethylene. It's a simple mobility The aim is to define the types of particles that cause the most tissue inflammation
PROCEDURE	hip prosthesis removed metal / polyethylene, double mobility	Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/polyethylene. It's a double mobility. The aim is to define the types of particles that cause the most tissue inflammation
PROCEDURE	hip prosthesis removed ceramic/ polyethylene, simple mobility	Patients are hospitalized in order to change for their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/polyethylene. It's a simple mobility. The aim is to define the types of particles that cause the most tissue inflammation
PROCEDURE	hip prosthesis removed ceramic/ polyethylene, double mobility	Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/polyethylene. It's a double mobility. The aim is to define the types of particles that cause the most tissue inflammation.
PROCEDURE	Primary implanted hip prosthesis	Patients are hospitalized in order to have a first hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The patients will be received a first prosthesis.
PROCEDURE	hip prosthesis removed metal/metal	Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/metal. The aim is to define the types of particles that cause the most tissue inflammation
PROCEDURE	hip prosthesis removed ceramic/ceramic	Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/ceramic. The aim is to define the types of particles that cause the most tissue inflammation

Timeline

• Start date: 2019-08-11
• Primary completion: 2024-07-09
• Completion: 2024-07-09
• First posted: 2019-04-02
• Last updated: 2025-12-05

Locations

2 sites across 1 country: France