NCT03887325

The Effects of Maxipost (BMS 204352) on Cerebral Hemodynamic and Headache in Healthy Volunteers and Migraine Patients

To Investigate the Headache Induction and the Cerebral Hemodynamic Changes After Infusion of Maxipost in Healthy Volunteers and Migraine Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

It is not previously investigated whether, there is a correlation between potassium channels and migraine, so it is unclear whether, this signaling pathway through potassium channels has an impact on migraine pathophysiology. Maxipost (BMS 204352) is a vasoactive molecule that causes vasodilation via the big calcium dependent potassium (BKCa) channel signaling pathway. Maxipost decreases the blood pressure and maxipost infusion causes headache in healthy volunteers. A possible coherence between maxipost and headache/migraine in healthy volunteers and migraine patients is yet to be investigated. The present study aims to clarify a possible coherence between maxipost and headache/migraine and it will help to shed light on the importance of potassium channels in migraine. In general, the study will contribute to a greater understanding of migraine pathogenesis and possibly lead to development of specific migraine treatment.

Conditions

• Headache, Migraine

Interventions

Type	Name	Description
DRUG	Maxipost	To investigate the role of maxipost on cerebral hemodynamic and headache in healthy volunteers and migraine patients
DRUG	Saline	To investigate the role of saline on cerebral hemodynamic and headache in healthy volunteers and migraine patients

Timeline

• Start date: 2019-04-01
• Primary completion: 2020-02-29
• Completion: 2020-02-29
• First posted: 2019-03-22
• Last updated: 2020-06-16

Locations

1 site across 1 country: Denmark