NCT03882099

Vitamin D Level and Its Relation to Pre-eclampsia and Eclampsia

Vitamin D Level in Patients With Pre-eclampsia, Eclampsia and Normal Full Term Pregnant

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 20 Years – 35 Years
• Healthy volunteers: —

Summary

To compare 25(OH)D level in patients with pre-eclampsia, eclampsia and normotensive pregnant women as well as to study the prevalence of Vitamin D deficiency among the 3 groups.

Detailed description

200 patients with pre-eclampsia, 100 with eclampsia and 200 normotensive pregnant controls attending Delivery/emergency department in Kasr Al Ainy hospital will be included in the study (from March 2019 till September 2019). 25(OH) D level will be measured for the three groups. * Preeclampsia is defined as systolic BP \>140 and/or diastolic BP\>90 on two occasions, 4 hours apart in pregnant females\>20 weeks, plus proteinuria \>/= 1+ urine dipstick protein. * Eclampsia defined as tonic-clonic seizures in women with pre-eclampsia. * Controls are normotensive pregnant females with no proteinuria and no other medical disorders. * The determination of 25(OH) D is based on a competitive enzyme-linked immunosorbant assay (ELISA) using the 25(OH)D3/D2 ELISA system (ORGENTIC DIAGNOSTIKA GmbH, Germany) Inclusion criteria: Age 20-35 years Gestational age 30-40 weeks Exclsion criteria: Twin pregnancy Other medical conditions during prrgnancy Drugs that influence Vit D levels eg.antiepileptics and antituberculous treatment.

Conditions

• Vitamin D Deficiency
• Pre-Eclampsia
• Eclampsia, Antepartum

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Determination of Vitamin D by ELISA	Blood samples

Timeline

• Start date: 2019-03-17
• Primary completion: 2019-09-17
• Completion: 2019-10-01
• First posted: 2019-03-20
• Last updated: 2019-03-20

Locations

1 site across 1 country: Egypt