NCT03877276

Dietary Oxalate and Immune Cell Function

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (estimated)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.

Detailed description

Inflammation and dietary oxalate have been shown to play an important role in the development of kidney stones. Oxalate is a small molecule found in plants and plant-derived food. Individuals that have high oxalate intake have an increased risk of developing kidney stones. The co-investigators have previously shown that healthy subjects that consume dietary oxalate have increased plasma and urine oxalate. White blood cells are essential for the immune response and rely on the mitochondria to carry out important cell functions. The Principal Investigator's current research shows that patients with calcium oxalate kidney stones have decreased mitochondrial function in their immune cells. Using the expertise of the investigators, this study will test whether oxalate has a direct effect on mitochondrial function in immune cells from healthy subjects. This information could help us understand the role of oxalate on the immune system during kidney stone pathogenesis.

Conditions

• Kidney Stone

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Breakfast	a prepared meal consisting of pastry and 2 cooked egg whites
DIETARY_SUPPLEMENT	Spinach smoothie	a prepared blended spinach smoothie, consisting of banana, avocado, orange juice, and spinach
DIETARY_SUPPLEMENT	Kale smoothie	prepared blended kale smoothie, consisting of banana, avocado, orange juice, and kale
DIETARY_SUPPLEMENT	Blended smoothie	a prepared blended smoothie, consisting of banana, avocado, and orange juice
DIETARY_SUPPLEMENT	V spinach smoothie	a prepared blended spinach smoothie, consisting of banana, avocado, orange juice, and a varying amount (low, medium, high) of spinach
DIETARY_SUPPLEMENT	Sodium oxalate drink	a prepared sodium oxalate drink

Timeline

• Start date: 2016-07-21
• Primary completion: 2026-06-01
• Completion: 2027-12-01
• First posted: 2019-03-15
• Last updated: 2025-06-09

Locations

1 site across 1 country: United States