NCT03877081

Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients

Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients, Randomized Control Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Hospital Civil de Guadalajara · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.

Detailed description

Acute kidney injury is most commonly caused by sepsis, where endotoxemia and an expanding inflammatory reaction play a key role in its pathogenesis, when this condition is present it is highly related to poor clinical outcomes and higher mortality rates. There is no current specific treatment, and the therapeutic approach is more orientated to complication management. In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.

Conditions

• Acute Kidney Injury
• Probiotics
• Sepsis

Interventions

Type	Name	Description
BIOLOGICAL	Probiotics	Administration of oral probiotics with 2 doses a day
OTHER	Placebo	Administration of oral placebo with 2 doses a day

Timeline

• Start date: 2019-01-04
• Primary completion: 2022-09-04
• Completion: 2023-02-04
• First posted: 2019-03-15
• Last updated: 2021-08-25

Locations

1 site across 1 country: Mexico