NCT03863431

The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Loughborough University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity. Following habitual diet, participants will be randomly allocated to either a high-carbohydrate or a high-fat diet intervention for 14-days. On days 0, 7 and 14 participants will undergo anthropometric and metabolic testing (primarily an oral glucose tolerance test \[OGTT\]).

Conditions

• Insulin Resistance
• Type 2 Diabetes
• Glucose Metabolism Disorders
• Metabolic Disease

Interventions

Type	Name	Description
OTHER	High-fat diet	Participants will consume a high fat diet for 14 days with approximately 65% of energy from fat. The diet will also provide an energy excess, at 130% of energy requirements. Participants will be provided with all of their meals and snacks throughout the study.
OTHER	High-carbohydrate diet	Participants will consume a high fat diet for 14 days with approximately 70% of energy from carbohydrate. The diet will also provide an energy excess, at 130% of energy requirements. Participants will be provided with all of their meals and snacks throughout the study.

Timeline

• Start date: 2019-05-22
• Primary completion: 2021-06-01
• Completion: 2021-06-01
• First posted: 2019-03-05
• Last updated: 2021-02-24

Locations

1 site across 1 country: United Kingdom