NCT03858231

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

The Effects of Combination Therapy of Opioids Versus Non-Opioids on Postoperative Pain Management After Knee Arthroscopic Surgery: A Prospective Randomized Controlled Study

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 148 (estimated)
• Sponsor: Sanford Health · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.

Conditions

• Knee Injuries
• Pain, Postoperative
• Opioid Use

Interventions

Type	Name	Description
DRUG	Norco 5Mg-325Mg Tablet	1 tablet up to 4 times per day for 7 days
DRUG	Ibuprofen 600 mg	1 tablet up to 4 times per day for 7 days
DRUG	Acetaminophen 325Mg Tab	1 tablet up to 4 times per day for 7 days

Timeline

• Start date: 2018-10-29
• Primary completion: 2027-12-01
• Completion: 2028-01-01
• First posted: 2019-02-28
• Last updated: 2026-02-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study