NCT03852303

Ivermectin Treatment of Persons With Onchocerciasis-associated Epilepsy

OAETREAT Extra Ivermectin Treatment of Persons With Onchocerciasis-associated Epilepsy: a

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 197 (actual)
• Sponsor: Universiteit Antwerpen · Academic / Other
• Sex: All
• Age: 5 Years
• Healthy volunteers: Not accepted

Summary

Randomized clinical trial in the Logo health zone, in Ituri province, Democratic Republic of Congo to compare seizure freedom in onchocerciasis infested epilepsy patients who ivermectin treatment once a year compared to 2 and 3 times a year. All participants also receive anti-epileptic drugs according to local guidelines for epilepsy treatment. Participants will be followed for 12 months. The primary endpoint is seizure freedom defined as no seizures during the last fourth months of the trial.

Detailed description

Randomized clinical trial in the Logo health zone, in Ituri province, Democratic Republic of Congo to compare seizure freedom in onchocerciasis infested epilepsy patients who ivermectin treatment once a year compared to 2 and 3 times a year. All participants also receive anti-epileptic drugs according to local guidelines for epilepsy treatment. Participants will be followed for 12 months.The primary endpoint is seizure freedom defined as no seizures during the last fourth months of the trial.

Conditions

• Epilepsy

Interventions

Type	Name	Description
DRUG	ivermectin	evaluate effect of ivermectin on frequency of seizures

Timeline

• Start date: 2017-10-01
• Primary completion: 2019-03-31
• Completion: 2019-07-01
• First posted: 2019-02-25
• Last updated: 2019-09-26

Locations

1 site across 1 country: Democratic Republic of the Congo