NCT03852082

Predictors and Clinical Outcomes of Patients With Coronary Heart Disease Co-morbid Depression Post Percutaneous Coronary Intervention

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,600 (estimated)
• Sponsor: Nanjing First Hospital, Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A prospective, multicenter, registered cohort study to observe the incidence of 1-year major adverse cardiac events in patients with coronary heart disease co-morbid depression treated with percutaneous coronary intervention and to clarify the predictors of 1-year major adverse cardiac events post PCI among these patients.

Detailed description

Coronary heart disease (CHD) is a clinical relevant psychosomatic issue. Treatment strategies include percutaneous coronary intervention (PCI), guidelines medication (GDMT) and coronary artery bypass grafting (CABG) were clinical proven to be effective to realize myocardial revascularization post CHD. Previous studies revealed that diagnosed depressed CHD patients have 3.6 times higher risk of major adverse events (MACE) post percutaneous coronary intervention than nondepressed. However, a reliable explanation of how depression impact clinical outcomes of CHD patients post PCI is lacking. The objective of this study is to observe the incidence of major adverse cardiovascular events in patients with coronary heart disease co-morbid with depression post PCI, and to explore a prognostic model of clinical outcomes based on physiological, interventional, socio-economic and psychological factors among these patients.

Conditions

• Coronary Heart Disease
• Percutaneous Coronary Intervention
• Depression

Interventions

Type	Name	Description
PROCEDURE	percutaneous coronary intervention	Patients with coronary heart disease co-morbid depression post percutaneous coronary intervention.

Timeline

• Start date: 2019-08-28
• Primary completion: 2026-12-30
• Completion: 2026-12-30
• First posted: 2019-02-22
• Last updated: 2026-04-13

Locations

1 site across 1 country: China