NCT03848741

Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D

Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D on Body Composition and Skeletal Muscle Health

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: Female
• Age: 45 Years – 60 Years
• Healthy volunteers: Accepted

Summary

During middle-age, humans begin to lose muscle mass and strength. With increasing age the deterioration of muscle health is associated with a decline in quality of life and the loss of independence. β-hydroxy β-methylbutyrate (HMB) plus Vitamin D (VitD) have been proposed to increase skeletal muscle mass, contractile function and improve body composition but has yet to be evaluated in middle-aged women. The overall goal of this study is to determine the effects of HMB +VitD supplementation during 12 weeks of resistance exercise training or a non-exercise control on body composition, skeletal muscle size, and skeletal muscle function in middle-aged women.

Detailed description

To determine if HMB+VitD supplementation is an effective strategy to help prevent the loss of skeletal muscle size, skeletal muscle function and body composition in middle-aged women, forty eight women (45-60 yrs old) will be recruited to complete a 12-week intervention (n=12 per group; 4 groups). Participants will be randomized to complete a non-exercise control period or a resistance exercise training program. In a double-blinded fashion, participants in the non-exercise or resistance exercise groups will be randomized to consume either placebo or HMB+VitD. Before and after each intervention the investigators will evaluate skeletal muscle size, skeletal muscle function, and body composition.

Conditions

• Aging
• Skeletal Muscle

Interventions

Type	Name	Description
BEHAVIORAL	Non-Exercise Control	Participants will not perform structured exercise and will continue with their normal physical activity for 12-weeks.
BEHAVIORAL	Resistance Exercise Training	Participants will complete a 12-week whole-body progressive resistance exercise training program.
DIETARY_SUPPLEMENT	Placebo	Participants will be given placebo capsules to consume for 12-weeks.
DIETARY_SUPPLEMENT	HMB+VitD	Participants will be given HMB+VitD capsules to consume for 12-weeks

Timeline

• Start date: 2019-04-01
• Primary completion: 2020-12-01
• Completion: 2021-04-01
• First posted: 2019-02-21
• Last updated: 2019-07-17

Locations

1 site across 1 country: United States