Trials / Unknown
UnknownNCT03844893
Macrophage Programing in Acute Lung Injury
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 56 (estimated)
- Sponsor
- National Jewish Health · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The histologic hallmarks of lung inflammation and in the extreme, acute respiratory distress syndrome (ARDS), include intense accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Mini bal | Mini-BAL is a minimally invasive technique frequently used in the investigator's local intensive care units (ICUs) to obtain alveolar fluid samples from mechanically ventilated patients. This is typically done for microbial analysis. |
Timeline
- Start date
- 2019-10-01
- Primary completion
- 2023-03-01
- Completion
- 2023-03-01
- First posted
- 2019-02-19
- Last updated
- 2019-08-22
Source: ClinicalTrials.gov record NCT03844893. Inclusion in this directory is not an endorsement.