NCT03841383

Association Between Coronary Flow Reserve and BH4 Levels in High CV Risk

Study to Investigate the Association Between Coronary Flow Reserve and BH4 Levels in Patients With High Cardiovascular Risk

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 55 (actual)
• Sponsor: IRCCS San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .

Detailed description

Primary parameter : relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with hypertension and concomitant cardiovascular risk factors. Secondary parameter: Levels of cGMP in platelets. 4\. Study design Three parallel groups of patients (n=15 per group): * Group 1 with normal coronary flow reserve (CFR ≥2.5) * Group 2 with reduced coronary flow reserve (CFR≤2.0) o Group 3 control subjects (without a high risk profile according to ESC score chart http://www.heartscore.org. ) matched for age (between 40 and 80 years of age) * and gender. 1/3 enrolled patients must be diabetic (Type2 diabetes)

Conditions

• Hypertension,Essential

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Echo stress dipyridamole	Echo stress dipyridamole

Timeline

• Start date: 2017-06-06
• Primary completion: 2019-05-31
• Completion: 2019-07-10
• First posted: 2019-02-15
• Last updated: 2019-07-12

Locations

2 sites across 1 country: Italy