Trials / Unknown
UnknownNCT03839069
Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
The Effects of Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- 20 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
This is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.
Detailed description
Cicatrizing conjunctivitis can be the common presentation of many ocular surface diseases as Stevens-Johnson syndrome (SJS), mucous membrane pemphigoid (MMP), chemical burn, Sjogren syndrome, chronic graft-versus-host disease (GVHD) and ocular trauma. Ocular dryness in combination with symblepharon and corneal opacity in these patients could lead to the poor visual and life quality, and less favorable prognosis of ocular reconstruction. This study aims to prospectively evaluate the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis. The investigators evaluate the saliva-tear productivity (functional outcome) and the survival of graft (anatomical outcome) every three months. The investigators would also validate whether minor salivary gland transplantation is beneficial for the participant prior to further ocular reconstruction as limbal transplantation and corneal grafting.
Conditions
- Cicatrizing Conjunctivitis
- Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
- Sjogren Syndrome
- Mucous Membrane Pemphigoid
- Chronic Graft Versus Host Disease
- Chemical Burn to Eye
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | minor salivary gland transplantation | The investigators will harvest the autologous labial salivary gland tissue and transplant to the upper and lower conjunctival fornix of the lesion eye. |
Timeline
- Start date
- 2016-09-01
- Primary completion
- 2020-12-01
- Completion
- 2021-06-01
- First posted
- 2019-02-15
- Last updated
- 2019-02-15
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT03839069. Inclusion in this directory is not an endorsement.