Trials / Completed
CompletedNCT03838458
Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces
Comparison of Structural and Molecular Genetic Properties Between Normal and Hypospadic Children's Prepuces
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 52 (actual)
- Sponsor
- Trakya University · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The aim of this study is to compare prepuce tissue samples from healthy male children who applied for circumcision and children with isolated hypospadias. Estrogen receptor 1 (ER1), androgen receptor (AR), FGFR2, transforming growth factor beta (TGF beta) and HOXA13 gene expression in the prepuce is planned to investigate via polymerase chain reaction (PCR) method. Mucosal vascular and nerve densities, and extracellular matrix density of laminin and collagen protein is planned to investigate via immunohistochemical examination.
Conditions
Timeline
- Start date
- 2019-01-07
- Primary completion
- 2020-01-07
- Completion
- 2020-03-10
- First posted
- 2019-02-12
- Last updated
- 2020-04-28
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT03838458. Inclusion in this directory is not an endorsement.