NCT03832062

Value of Analysing Under-utilised Leftover Tissue (VauLT)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: Royal Marsden NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Intratumour heterogeneity is well recognized in multiple cancer types and ultimately leads to therapeutic resistance. It also limits the ability of small samples to represent the whole tumour, having implications for diagnosis, molecular analysis and understanding of the tumour immune microenvironment. By blending- 'homogenizing'- leftover tumour tissue in excess of that required for diagnosistic purposes, one may create a more representative sample for analysis.

Detailed description

In order to establish the feasibility of homogenization as a potential companion diagnostic tool, our study aims to 1) evaluate how many surgical cases have left over tissue amenable to homogenization and 2) pilot homogenization across multiple tumour types. The molecular profile of the homogenate will be compared to that obtained from the diagnostic specimen using next generation sequencing techniques.

Conditions

• Oncology

Interventions

Type	Name	Description
OTHER	Leftover surgical tissue homogenization	Leftover surgical tissue homogenization

Timeline

• Start date: 2018-09-10
• Primary completion: 2028-08-31
• Completion: 2028-12-31
• First posted: 2019-02-06
• Last updated: 2025-05-18

Locations

1 site across 1 country: United Kingdom