NCT03829592

TheEffect of pH on Misoprostol in Induction of Labor

TheEffect of pH on Misoprostol in Induction of Labor in Full Term Pregnancies

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Aljazeera Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 42 Years
• Healthy volunteers: Accepted

Summary

Misoprostol is a synthetic analogue of the naturally occurring prostaglandin E1. It was initially marketed for the treatment of peptic ulcers due to its mucosal protective and anti-secretory properties, but has commonly been used for the induction of abortion and labour .

Detailed description

Although initially having been established for oral use, misoprostol tablets are commonly used as vaginal suppositories for the previously purposes. Water or saline are frequently used in common practice to moisten the tablets prior to their administration, however, according to the pharmacokinetics of the drug, it should liquefy better in an acidic medium

Conditions

• Labor Pain

Interventions

Type	Name	Description
DRUG	misoprostol in a neutral media	giving misoprostol in a neutral media
DRUG	misoprostol in an acidic media	giving misoprostol in an acidic media
DRUG	misoprostol in an alkaline media	giving misoprostol in an alkaline media

Timeline

• Start date: 2019-02-06
• Primary completion: 2020-05-10
• Completion: 2020-07-12
• First posted: 2019-02-04
• Last updated: 2020-05-19

Locations

1 site across 1 country: Egypt